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HomeEndometriosisEndometriosis ResearchVitamin D deficiency as a risk factor for endometriosis

Vitamin D deficiency as a risk factor for endometriosis

The vitamin D and endometriosis connection you should know about. Endometriosis is still a poorly understood condition. At our institute we are constantly looking for the most updated information regarding endometriosis treatment. This is an interesting article which we hope will help you understand at least this part of endometriosis treatment.

If this article seems to apply to your situation, please reach out to us and Dr. Steven Vasilev, our director. Since we are monitoring this research as it gets published, we can use it to help you beat endo and get your life back. Dr Steven Vasilev is a renowned robotic endometriosis excision expert, focusing on recurrent and advanced endometriosis excision.

Nutrition is a key underpinning to health and avoiding diseases like endometriosis and cancer.  In fact there are a few KEY vitamins that are almost too good to be true.  The vitamin D to endometriosis connection is clarified by this study.   See below for TRANSLATION.

J Reprod Immunol. 2020 Dec 17;143:103266. doi: 10.1016/j.jri.2020.103266. Online ahead of print.


PURPOSE: Vitamin D (Vit D), as an immunomodulator, has been hypothesized to play a critical role in the pathogenesis of endometriosis. Thus, in this study, we evaluated whether there is an association between 25-hydroxyvitamin D [25(OH)D] and susceptibility to endometriosis in Iranian women.

METHODS: Women at reproductive age, including 56 healthy women and 54 patients with endometriosis, were enrolled in the study. Serum levels of 25(OH)D, calcium, parathyroid hormone (PTH), and peritoneal fluid (PF) levels of 25(OH)D were assessed.

RESULTS: The serum and PF levels of 25(OH)D in the patients with endometriosis were significantly lower than the control group (P = 0.001 and P = 0.03, respectively). Subjects with serum levels of 25(OH)D lower than 20 ng/mL had a 2.7 times higher risk of endometriosis than people with 25(OH)D serum levels higher than 20 ng/mL (non-deficient) (OR = 2.7, 95 % confidence interval: 1.24-5.80, P = 0.01). The serum levels of calcium and PTH were significantly lower and higher in patients with endometriosis compared with controls, respectively (P < 0.001, P = 0.02, respectively). Also, the serum levels of 25(OH)D were lower in stages I-II endometriosis than stage III-IV; however, no significant difference was observed.

CONCLUSION: Our findings showed that people with Vit D deficiency are at higher risk of endometriosis.

PMID:33385732 | DOI:10.1016/j.jri.2020.103266

Ali-Akbar Delbandi


TRANSLATION: This is a small study in Iranian women specifically but supports many others out there regarding the clinical health benefits of Vitamin D in everyone.  You can’t depend on the sun because even 30% of people who live in the “sunbelt” are still deficient.  The minimum recommended daily intake is ~800IU but most experts feel this is WAY too low of a dose.  In most cases 1000 to 2000IU per day works, but work with your doctor and get your blood levels checked. That is the best way to tell if you are in a good range.


This book by Dr. Steven Vasilev MD can help women with ovarian cysts, masses and tumors of all types, including endometriosis and endometriomas.  He is a world-renowned expert on this topic.

To discover more about endometriosis and our unique treatment approach, please READ THIS


Dr Steve Vasilev MD
“I help and guide women to defeat gynecologic cancers and advanced pelvic conditions such as endometriosis, using a unique combination of minimally invasive robotic surgery, precision medicine therapies and complementary holistic natural support towards thriving in survivorship." Dr. Vasilev is the only physician quadruple board certified in Ob-Gyn, Gynecologic Oncology and Integrative & Holistic Medicine in the United States. He is an accomplished advanced robotic surgeon and serves as Medical Director of Integrative Medicine and Integrative Gynecologic Oncology at Providence Saint John's Health Center, Professor at John Wayne Cancer Institute in Santa Monica, California and is Clinical Professor at Loma Linda University School of Medicine. He is former faculty and professor at UC Irvine, UCLA, USC and City of Hope. He is an active member of multiple medical societies and has been nationally listed in "Best Doctors" for 18 years.

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