Monday, April 19, 2021
HomeUterine CancerEndometrial CancerEndometrial cancer patients in Kentucky have a higher rate of DACH1 mutations

Endometrial cancer patients in Kentucky have a higher rate of DACH1 mutations

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This is a study that is interesting because the reasons why some patients with uterine cancer have far worse survival is elusive.  It is known that certain cell types can be more aggressive, like papillary serous (UPSC) and clear cell, but even in those, there is a difference in outcomes that has yet to be explained.  This sheds some light on at least one possible reason and provides a possible targeted therapy strategy as well.  The study was performed on patients in Kentucky but this may apply to patients in other areas as well, which remains to be determined.

“A new study by researchers at the University of Kentucky’s Markey Cancer Center shows that DACH1 mutations are widespread in endometrial cancer patients in Kentucky, suggesting that DACH1 could be a potential biomarker for future immunotherapy studies.

DACH1 is a transcriptional repressor and tumor suppressor gene that is commonly mutated in other cancers, including melanoma, bladder and prostate cancers. Loss of DACH1 expression is also linked to poor prognosis and decreased survival in women with uterine cancer.

The study, published in PLOS One, attempted to determine the frequency of DACH1 mutations in patients with endometrial cancer in Kentucky. Using the Oncology Research Information Exchange Network (ORIEN), a personalized medical consortium that Markey joined in 2017, researchers examined clinical and genomic data from 65 Kentucky patients with endometrial cancer. The data was compared to the endometrial cancer population from the National Cancer Institute’s cancer genome atlas, which contains genomic data from more than 22,000 diagnosed primary cancers from across the country.”

For More information:
McKayla J. Riggs et al. The frequency of DACH1 mutations in endometrial cancer is associated with a high burden of tumor mutations, PLOS ONE (2020). DOI: 10.1371 / journal.pone.0244558 Provided by the University of Kentucky

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Dr Steve Vasilev MD
“I help and guide women to defeat gynecologic cancers and advanced pelvic conditions such as endometriosis, using a unique combination of minimally invasive robotic surgery, precision medicine therapies and complementary holistic natural support towards thriving in survivorship." Dr. Vasilev is the only physician quadruple board certified in Ob-Gyn, Gynecologic Oncology and Integrative & Holistic Medicine in the United States. He is an accomplished advanced robotic surgeon and serves as Medical Director of Integrative Medicine and Integrative Gynecologic Oncology at Providence Saint John's Health Center, Professor at John Wayne Cancer Institute in Santa Monica, California and is Clinical Professor at Loma Linda University School of Medicine. He is former faculty and professor at UC Irvine, UCLA, USC and City of Hope. He is an active member of multiple medical societies and has been nationally listed in "Best Doctors" for 18 years.

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